Monday, October 26, 2020

Ca Breast Chemotherapy

Afinitor Everolimus Afinitor Disperz Everolimus Alpelisib. This class of drugs.

Chemotherapy National Breast Cancer Foundation

Node-positive cancers tumor 1 cm node-negative cancers of 05 cm with adverse prognostic features blood vessel or lymph vessel invasion high histologic grade HER-2neu overexpression and negative hormone receptor status.

Ca breast chemotherapy. It can also help reduce some symptoms. DOXOrubicin and Cyclophosphamide Followed by PACLitaxel and Trastuzumab. Doctors usually offer chemotherapy to treat early stage stages 1A 1B and 2A breast cancer with a high risk of recurrence or locally advanced stages 2B 3A 3B and 3C breast cancer.

There are quite a few chemotherapy medicines. Because chemotherapy medicines affect the entire body chemotherapy is commonly used to treat advanced-stage breast cancer. The drugs used will depend on the womans age as well as tumor test results including hormone-receptor status and HER2 status.

AC chemotherapy can be used to treat primary breast cancer breast cancer that hasnt spread beyond the breast or the lymph nodes under the arm. Chemotherapy often shortened to just chemo is a systemic therapy which means it affects the whole body by going through the bloodstream. It is endorsed by the American Joint Committee on Cancer AJCC.

Common Chemotherapy Drugs for Breast Cancer Chemotherapy drugs used to treat early breast cancer include. Chemotherapy is used to treat. Chemotherapy can shrink or slow the growth of secondary breast cancer.

Metastatic cancer is considered stage IV. In many cases a combination of two or more medicines will be used as chemotherapy treatment for breast cancer. Your cancer doctor or specialist nurse will talk to you about the benefits of chemotherapy in your situation and explain the likely side effects.

Chemotherapy for breast cancer can be given either before or after surgery to remove the cancer. Recognize histologic features of tumor bed and post-chemo carcinoma including pitfalls Understand reporting schemes utility and clinical impact of residual tumor burden. Surgical removal of both breasts is another preventive measure in some high risk women.

Sometimes its used in combination with other anti-cancer drugs. CHEMOTHERAPYCHEMOTHERAPY Adjuvant chemotherapy for early invasive breast ca is indicated in all patients with. Drugs Approved to Treat Breast Cancer.

In those who have been diagnosed with cancer a number of treatments may be used including surgery radiation therapy chemotherapy hormonal therapy and targeted therapy. Types of surgery vary from breast-conserving surgery to mastectomy. Document if tumor bed at specimen edge esp if residual scattered ca.

Capecitabine if triple-negative breast cancer TNBC and residual disease after preoperative therapy with taxane- alkylator- and anthracycline-based chemotherapy. Chemotherapy for Breast Cancer Chemotherapy chemo uses anti-cancer drugs that may be given intravenously injected into your vein or by mouth. Chemotherapy for these stages of breast cancer is generally given as a combination of several drugs because research shows that giving them together is more.

The drugs travel through the bloodstream to reach cancer cells in most parts of the body. Chemotherapy is used to treat advanced-stage breast cancer by destroying or damaging the cancer cells as much as possible. Evista Raloxifene Hydrochloride Raloxifene Hydrochloride.

Category 1 45 Days 1-14. Chemotherapy given before surgery is called primary or neo-adjuvant chemotherapy. Occasionally chemo may be given directly into the spinal fluid which surrounds the brain and spinal cord.

Chemotherapy can be given to people with secondary breast cancer when breast cancer cells have spread to another part of the body. Chemotherapy is given to reduce the risk of breast cancer returning or spreading. Soltamox Tamoxifen Citrate Tamoxifen Citrate.

Predict is an online tool that helps patients and clinicians see how different treatments for early invasive breast cancer might improve survival rates after surgery. Abraxane Paclitaxel Albumin-stabilized Nanoparticle Formulation Ado-Trastuzumab Emtansine. To help decide which women with stage II hormone receptor-positive Her2-negative breast cancer will benefit from chemotherapy a gene panel test such as Oncotype DX may be done on the tumor sample.

Drugs Approved to Prevent Breast Cancer. Neoadjuvant or Adjuvant Therapy for Breast Cancer Using Dose Dense Therapy.

Saturday, October 24, 2020

Benefits Of Daily Vitamins

However the vitamins should be taken as prescribed to avoid putting your health at risk. What Are the Benefits of Taking One-A-Day Mens Formula Multivitamins.

Herbalife Vitamins And Minerals Benefits Vitamins And Minerals In Eggshells Vitamins And Minerals Bioch Vitamin A Foods Daily Vitamins Diet And Nutrition

Daily Vitamins Can Improve Eye Health Taking good care of your eyes is super important and taking a daily vitamin is a great way to boost your eye health.

Benefits of daily vitamins. Vitamin E does not prevent wrinkles or slow other aging processes. Vitamins strengthen a persons immunity and should be part of your daily routine. Should be taken regularly by all women of child-bearing age since women may not know they are pregnant in the first weeks of pregnancy.

Mens One A Day Multivitamin. Our metabolism determines how efficiently we are able to make use of consumed food and. Unsere hochwertigen Camu Camu Kapseln sind die Lösung.

You could start with Vitamin C which is an antioxidant and then add Vitamins E and D. Nutritionists claim it to be the safest to take with the benefits getting to work though some people may experience stomach irritation. Protects Your Eyes From Night Blindness and Age-Related Decline.

These vitamins work together to help your body. Promotes Immune System Health. Notably vitamin C enhances the absorption of calcium in the intestines 21.

Anzeige Daily Vitamin Test und Vergleich. Mens One A Day vitamins provide varying amounts of 21 vitamins minerals and. 12 Amazing Health Benefits of Vitamins 1.

Neukundenrabatte und verschiedene Zahlungsmethoden stehen zur Auswahl. The B-complex group of vitamins includes vitamins B-6 and B-12 as well as thiamin riboflavin niacin folate biotin and pantothenic acid. One of the benefits of this increased absorption is greater bone mass density and.

So what are the benefits of daily consumption of vitamins. Große Auswahl an Vitaminen Mineralien Vitalstoffen für Ihre Gesundheit. 6 Health Benefits of Vitamin A Backed by Science 1.

FOLIC ACID vitamin B 9 folate folacin Vital for new cell creationHelps prevent brain and spine birth defects when taken early in pregnancy. One of the most important roles vitamins play in our body is. Found in fruits and vegetables a healthy daily dose of Vitamin C has been purported to bolster immunity protect against cardiovascular disease eye disease and wrinkles.

May Lower Your Risk of Certain Cancers. Jetzt Daily Vitamins vergleichen online bestellen Geld sparen. Nutrient Amounts Men Need.

Vitamin A is essential for preserving your eyesight. Anzeige Vitamine Mineralien und Vitalstoffe für eine gesunde Ernährung. On the Supplements Facts section of.

Die besten Produkte aus 2021 gesucht. There is a relationship between vitamin C and calcium. The Surprising Health Benefits of Multivitamins Bonus Benefits.

Going back to the synergy between different nutrients. Große Auswahl an Vitaminen Mineralien Vitalstoffen für Ihre Gesundheit. Anzeige Vitamin C Mangel.

Natürliches Vitamin C Hochdosiert hochwertige Qualität und rein pflanzlicher Herkunft. How to Find a High-Quality Multivitamin. Unser Test- und Vergleichsverfahren ist unabhängig objektiv und TÜV-zertifiziert.

Anzeige Vitamine Mineralien und Vitalstoffe für eine gesunde Ernährung. Anzeige Niedrige Preise Riesen-Auswahl. Anzeige Daily Vitamin Test Vergleich.

Anzeige Bei uns finden Sie Vitamin A Pulver in bester Kosmetikqualität. Cancer occurs when abnormal cells begin to grow or divide in an uncontrolled. The mens One A Day multivitamin supplement was developed to address the specific health.

Women taking multis were less hungry while losing weight on a diet and exercise program and men on the. Good nutrition reduces the risk of age-related eye problems like macular degeneration.

Wednesday, October 21, 2020

Home Prices In Kentucky

Currently Kentucky homes are selling for an average of 145400 according to July data from Zillow. The average sale price of a home in Louisville was 228K last month up 86 since last year.

Record Breaking Year For Kentucky Housing Market Total Home Sales Highest Ever Recorded Kyforward Com Kyforward Com

Average Home Price in Louisville Kentucky Chart of 3-Year Average Home Price in Louisville Kentucky through March 2021.

Home prices in kentucky. Use our patented search to check KY home appreciation rates average house values rental prices the current housing market forecast historical real estate trends and more. Find cheap homes for sale view cheap condos in Kentucky view real estate listing photos compare properties and more. 15144 homes for sale in Kentucky priced from 10000 to 13900000.

Ranking based on data from the US. The mortgages are serviced by the KHC and maintained in Kentucky not sold off the way other mortgages are. Know before you buy in Kentucky.

Of the total homes in Kentucky 96 are for sale 4 are for rent and 67 are single family homes. 1626 Rangeland Rd Louisville 195000 3 bedrooms. HOMES 500001 to 750000.

Read more on how this ranking was calculated. There are currently 23632 properties with a median home value in Kentucky of 135000. Homes in Louisville receive 4 offers on average and sell in around 23 days.

View listing photos review sales history and use our detailed real estate filters to find the perfect place. 7370 single family homes for sale in Kentucky. HOMES 250001 to 500000.

Per this chart the current average home price in Louisville is 249183. Browse 2449 cheap houses for sale in Kentucky priced up to 200000. View photos see new listings compare properties and get information on open houses.

--- 220 less than typical home price in Kentucky - Pictured. In comparison the average price range for a manufactured homes construction is 45 -. In Kentucky a big part of their culture is the Kentucky Derby and with a population of just under 45 million many individuals call Kentucky home.

The median list price per square foot in Kentucky is 93. A minimum credit score of 660. This median list price means that the average house in.

A down payment of 3 of your purchase price. Census FBI and other data sources. To qualify for this program youll need.

HOMES 750001 to 1000000. Explore the best places to buy a house based on home values property taxes home ownership rates housing costs and real estate trends. The Louisville housing market is very competitive.

The average sale price per square foot in Louisville is 127 up 134 since last year. These home loans have 30-year fixed interest rates so your rate wont change over the life of the loan. The median price of homes sold this past month is 208000.

Here are the three communities with populations of at least 35000 in Kentucky. The typical single-family home value is about 34 times higher than the local median household income of 43369. Zillow has 14597 homes for sale in Kentucky.

For nearby or other top Kentucky real estate home values or foreclosures see our additional real estate links. The average sales price of a home in Kentucky is 193000. Kentucky wa Housing Market.

View pictures of homes review sales history and use our detailed filters to find the perfect place. Search for home values and property records in Kentucky by selecting one of the top home values markets listed or by using our alphabetical directory of Kentucky counties. Kentucky represents 1 of home addresses in the United States.

Tuesday, October 20, 2020

Why Does It Smell After My Period

This infection in turn would cause the foul smelling period. Your period can produce an odor which may even be different month to month.

Why Does My Period Smell Death Fishy Rotten And More

If you have a smelly white discharge after menses then there is a possibility of a thrush or a yeast infection due to Candida albicansThis occurs when the natural balance of bacteria in the vagina is altered by the hormonal changes leading to multiplication of the fungi.

Why does it smell after my period. Some women report that their period smells like death though this isnt necessarily a cause for concern. These infections often expel colored spotting with foul smell a few days after period. Check to make sure you have not forgotten to remove a previous tampon.

Even when the result is negative repeat the same a week after the date you expected to see your period especially if you missed the period. Because of this you might also notice a fishy vaginal odor after your period. This provides an idle environment for bacteria to flourish and thereby cause infection.

Sometimes vaginal bacteria become unbalanced. Citrus fruits may cause sweet smell or taste. Period blood can have a metallic smell like a copper coin.

This is typically due to the presence of iron in the blood and is not usually a cause for. The vaginal pH goes from acidic to alkaline during your period. A particularly strong fishy.

A foul odor may suggest the std trichomonasUse of lubricants or birth control options can change the odorYeast infections may smell like bread and often have a thick white dischargeThe presence of blood changes the odor. Sometimes a fishy vaginal odor crops up just before the start of your period due to changing bacteria and acidity levels. Another typical smell you may experience during or after your period is a mild rotten smell.

Man Complains About His Wifes Strong Vaginal Odor. Menstrual fluid is filled with bacteria vaginal mucus and tissue you know since youre shedding the lining of your uterus How strong the odor is depends on how long the blood is in your. In reply to bbfeet964662 on 2008-04-26 - click to read.

If the sweet smell occurs about the time you expect your period you should take a pregnancy test given that it could be a sign of a pregnancy. A foul odor after period can sometimes be a. This smell is a result of blood and tissues exiting the vagina combining with bacteria on the outside of our bodies.

Your period blood is. I went to the gyno and she told me douching is probably one of the worst things you can do to your vagina it kills the good bacteria you have down there and it can cause vaginosis. Some medical conditions can explain why the vagina might itch after your period.

Normal vag odor may be muskyA fishy odor suggests a bacterial vaginosis. Because the odor has nothing to do with hygiene says Lauren Streicher MD Medical Director of the Northwestern Medicine Center for Sexual Medicine and Menopause. Post-menstruation vaginal smell Foul vulva Odor fishy smell no discharge no cramps Very Strong Vaginal Odor after my period with no.

During menstruation the blood which has an elevated pH and uterine lining mix with vaginal microflora subtly altering the smell. I had vaginosis because I used to douche to stay fresh and clean. Greves says but if all of a sudden your period smells seriously rotten you may want to talk to your doctor.

5 year old vaginal infection its smelly and she is having a poop like discharge Brown vaginal discharge and foul odor vaginal odor foul vaginal odor like feces what is it. Heres Why That Can Happen Bacterial Vaginosis. Therefore a bad smell after period may be caused by a vaginal infection or disease and most common symptoms of these infections besides the bad odor are abundant discharges in larger amounts than usually itching in the genital area or even pain.

The metallic scent shouldnt linger too long after your period is over. Period the many things that can leave an after-sex smell in your vagina. Symptoms include an itchy vagina watery discharge a different color of discharge an odor thats stronger than normal especially after intercourse or an unpleasant odor.

Bacterial infections Bacterial vaginosis and yeast infections Candida albicans are two of the most common infections that occur in women. If your vagina has had contact with semen this may change the pH level and cause a metallic smell. A slight change is usually nothing to worry about Dr.

A foul odor from your menstrual blood may indicate a foreign body in the vagina. Why does my poop smell so bad.

Saturday, October 17, 2020

Sesame Care Funding

Sesame a NYC-based direct-pay healthcare marketplace raised an additional 24m in funding. Sesame services are paid directly separate from health insurance.

Healthcare Disruptors Startup Tweaks Platform For Covid 19 Telemedicine Medpage Today

Sesames mission is to ensure quality care is accessible to all Americans who need it regardless of their insurance status while benefiting clinicians Lists Featuring This Company Greater New York Area Wellness Companies 498 Number of Organizations 68B Total Funding Amount.

Sesame care funding. The latest funding brings Sesames total capital raised to just under 50 million since it launched in 2019 the release said. See all 7 articles Loading Money. Sesame Managed Care Co-Founder Chief Executive Officer and Board Member.

Financial Technology Partners LP acted as an exclusive strategic and financial advisor to Credit Sesame for this round. How much credit am I given when I sign up. Direct-payment healthcare marketplace Sesame has added 24 million in new funding.

1 Sesame Street Funding Pilots 2 Sesame Street Funding 1969-1970 3 Sesame Street Funding 1970-1971 4 Sesame Street Funding 1971-1972 5 Sesame Street Funding 1972-1973 6 Sesame Street Funding 1973-1974 7 Sesame Street Funding 1974-1975 8 Sesame Street Funding 1975-1976 9 Sesame. How to load money to your Sesame. How do I freeze my card.

Some of these plans include a debit card you can use to pay up front and others require you to submit your receipt after your purchase. By putting power back in the hands of patients and doctors Sesame cuts out the middlemen that drive up costs to save you up to 60 on your care. What the Sesame team has built in the last year has the promise.

If your insurance includes a health savings account HSA or flexible spending account FSA you can use your funds from these accounts to pay for care on Sesame. Are there any fees. Enabling safe patient-centred care delivered by a competent and confident healthcare workforce in a well-functioning healthcare system.

No need to wait for your card to arrive start spending with Sesame Cash within minutes of funding your account with an instant virtual debit card you can use online or to pay bills. The new 42 million in funding is comprised of 266M in equity and 155M in venture debt bringing the San Francisco-based fintech companys total funding to over 77 million. Without the complexities of insurance and other traditional healthcare systems and hoops to jump through you get clear care that.

It is envisioned that the strategy will be reviewed annually at the SESAM Annual Retreat to ensure it. Sesame care is a healthcare platform that embraces direct-to-patient care putting the power back in the hands of the people by cutting out outdated inefficient systems and processes so that everyone has access to high-quality care at affordable prices. When will I receive my Sesame Cash debit Mastercard.

Backers included Giant Ventures Industry Ventures. I had to catch this quick be fore it went off. Donate today to support The Sesame Street Yellow Feather Fund which brings education to children in need helping them grow smarter stronger and kinder.

This funding credits has New Balance Beaches American Greetings McDonalds Earths Best OrganicNO COPYRIGHT INFRINGEMENT INTENDED Credit goes to DigiGirl. 476M link Sesame is a direct-pay health care company that connects doctors and patients directly. Investments from new backers included Giant Ventures Industry Ventures and Coefficient Capital in addition to existing investors General Catalyst Entree Capital and Atreides Management.

Sesame Cash debit works with Apple Pay Google Pay and Samsung Pay. Ive enrolled in Sesame Cash. Its the way healthcare should be.

In order to achieve our mission and vision we have developed a strategy with 5 strategic goals each with specific objectives and implementation plans. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy Safety How YouTube works Test new features Press Copyright Contact us Creators. We serve asset managers family offices and institutional investors in Switzerland and provide them with one of the most flexible and innovative open-architecture service platforms.

Doctors on Sesame list their own prices availability and services - without insurance mark-ups or surprise bills. Sesame Financial Group is a Geneva-based independent investment boutique and emerges as a leader in the tailored investment solutions and services industry. Its not too good to be true.

5g Phone Radiation

5G is much more dangerous than previous cellular technologies because it uses millimeter waves of much higher frequencies. 5G is expected to increase performance and a wide range of new applications including strengthening e-Health telemedicine remote surveillance telesurgery.

5g Is Being Rolled Out In Australia Is The Radiation Safe Hack Triple J

While many of the specifics of 5G remain ill-defined it is known that 5G cell phones will use frequencies covered by the current FCC exposure guidelines 300 kHz-100 GHz and the conclusions.

5g phone radiation. We dont know for sure if RF radiation from cell phones can cause health problems years later. Here is a link to letters from 250 scientists from 35 countries talking about the dangers of 5G. Even the FDA has been quoted as saying that the levels of radiation emitted by 5G and cell phones are low enough to be deemed acceptable for healthy public use.

Radiation protection can be easy with the right solution for anti-radiation to protect you and your family and frankly thats what we offer. Within the radio frequency portion of the electromagnetic spectrum the higher the frequency the more dangerous it is. Some 5G conspiracy theorists contend that the new network generates radiofrequency radiation that can damage DNA and lead to cancer.

27 February 2020 QA. There you have it. Even if you opt to use 5G down the road that will undoubtedly transmit more radiation the protective case should still help to reduce overall radiation reaching your brain.

Microwave and millimeter wavelength radiation which is one of the key blocks of spectrum that 5G service will use is also considered non-ionizing as is visible light and doesnt produce the. 5G Cell Towers are more dangerous than earlier cell tower generations because they expose us to a wider variety of RF Radiation frequencies. In common terms that means that the radiation will be more powerful but would have a relatively short range.

Harnessing millimeter wave mmWave spectrum for faster data speeds is one of the biggest breakthroughs of 5G the next-generation of cellular technology following 4G. Not only do they emit the higher 5G microwave frequencies between 24 GHz to 300 GHz but they emit many of the lower 2G 3G 4G frequencies as well between 1 GHz to 6 GHz. An article in the BBC explained The radio waves involved in 5G and other mobile phone technology sit on the low-frequency end of the electromagnetic spectrum.

If you dont own any of the phones mentioned in the list above get an FCC certified cell phone radiation shield. 5G mobile networks and health. RF is different from other types of radiation like x-rays that we know can be harmful.

The Smart 5G Shield is designed to block harmful RF radiation from common sources such as 4G and 5G cellphones tablets laptops and any other electronic devices. Most evidence shows that 5G devices emit radiation at much lower levels than what could affect humans. Tested in FCC certified laboratories DefenderShield protective case blocks almost 100 of EMF radiation emitted by the cell phones.

5G will typically not produce more radiation than 4G when comparing the total amount of radiation generated however 5G uses a higher frequency waveform so it can cause more bodily harm to us if we are directly exposed to it. Less powerful than visible light they are not strong enough to damage cells unlike radiation at the higher frequency end of the spectrum which includes the suns rays and. In order to achieve that the 5G radiation waves have to have higher frequencies.

5G or fifth generation is the latest wireless mobile phone technology first widely deployed in 2019. Your phone wouldnt give off more radiation. The lowest radiation emitting smartphones available on the market in 2020 offers a large selection of brands and technological possibilities with relatively reduced SAR levels.

Yes cell phones and cordless phones use radiofrequency radiation RF to send signals. And potentially lead to other diseases through the generation of stress proteins. The International Agency for Research on Cancer IARC has classified RF radiation as a possible human.

Cause oxidative damage that can cause premature aging. 5G is touted as a spectrum that allows more data transfer caps at higher speeds.

Percentage Of Americans Vaccinated

1081471762 Seychelles. DALLAS AP Disneyland reopened on Friday and cruise lines welcomed the news that they could be sailing again in the US.

Kff Covid 19 Vaccine Monitor December 2020 Kff

About 40 percent of adult Americans are fully vaccinated but polls suggest that a significant portion of the population does not plan to get inoculated.

Percentage of americans vaccinated. As of Tuesday about 40 percent of Americans have been fully vaccinated against the coronavirus. Today 100 million Americans are fully vaccinated nearly double the 55 million who were fully vaccinated at the end of March. The CDC also states over 43 percent.

Among the millions of vaccinated Americans 5800 people still got the virus as of April 13 the CDC confirmed to Best Lifethis week. 0142 3 hrs ago. WASHINGTON President Joe Biden wants 70 of US.

Hes focusing on easing access to shots as his administration. Roughly 783 million Americans ages 18 years and older have been fully vaccinated representing 303 percent of the population of that age group according to. Of population Per 100 people Total Vaccinated Fully vaccinated.

April 22 2021 901 AM. President wants 70 of Americans partially vaccinated by July 4th. Anthony Fauci President Joe Bidens chief medical adviser said he thinks the share of people who need to be vaccinated for the USA to reach herd immunity is somewhere between 70 to 90.

The Centers for Disease Control. Fully vaccinated 39 percent of its adult population Credit. For the past nine days daily vaccinations nationwide have declined.

A growing number of Americans have missed their scheduled second dose of a Covid-19 vaccine according to data from the US Centers for Disease Control and Prevention. WLNSAccording to the Centers for Disease Control and Prevention nearly 101 million Americans are fully-vaccinated against COVID-19. About 2 in 5 American adults are now fully vaccinated.

The number of Americans getting vaccinated is on the decline. In total 17 percent of the US population is completely vaccinated while 30 percent have received at least one shot according to the Centers for Disease Control and Prevention Data tracker. Is averaging 24 million reported vaccinations per day over the past week down from a.

14 more than 234 million doses have been administered fully vaccinating over 979 million people or 295. Thirty-nine percent of the nations adult population has been fully vaccinated according to the Centers for Disease Control and Prevention. A hundred million Americans who can follow the new CDC guidance released this week and enjoy going to the park with their family.

Adults to have at least one COVID-19 shot by July 4 a goal he announced Tuesday along with steps to vaccinate harder-to-reach populations and. But for ships to cruise again 98 percent of the crew and 95 percent of passengers need to be fully vaccinated according to a CDC letter to the industry that was obtained by USA Today. Since COVID-19 vaccine distribution began in the United States on Dec.

By David Koenig Amy Taxin and Mae Anderson. As he outlined new initiatives including vaccinating adolescents and increasing the number of walk-up clinics Biden also announced a new goal. Three vaccines to prevent Covid-19 infections have now been granted authorization for emergency use and every day thousands more people are becoming vaccinated.

That 70 percent of American adults would be vaccinated by the Independence Day holiday now two months away. At that time more than 75. Number Of Americans Fully Vaccinated Tops 100 Million.

Thirty-nine percent of the nations adult population has been fully vaccinated according to the Centers for Disease Control and Prevention. Doses administered Pct. Thats 100 million nearly 40 percent of all adult Americans who.